Post-acute sequelae of SARS-CoV-2 infection (PASC) have been shown to vary by race/ethnicity, but evidence is limited for children and adolescents. Here, the authors investigate variations in PASC by race/ethnicity in those aged under 21 years using electronic health record data from the United States.
The OMICRON SARS-COV-2 BA. 86 line has more than 30 mutations compared to the parental line BA. 2. Here, Bdir and his colleagues apply a mutational scan opposite to which of these mutations it provides in OMICRON BA. 2. 86 Epitopes similar to the immune evasion of antibody recognition.
Long Fung Chau and colleagues report the generation of transgenic pigs expressing human ACE2, and show that they exhibit clinical signs and immunopathology consistent with COVID-19 following infection with SARS-CoV-2, suggesting that human ACE2 transgenic pigs are a viable large animal model for COVID-19.
A unified deep learning framework for evolution is presented, which outperforms strategies through diverse predictions of viral mutational drivers, and which captures basic patterns of virus evolution.
Phosphorothioate-linked guanosine 12mer inhibits the interaction of viral genomic RNA with nucleoprotein in the cytoplasm, suppressing the proliferation of coronaviruses and influenza A viruses that have the potential to cause future pandemics.
The severity of Covid-19 is connected to the formation of Microthrombus. Here, a two-photon in vivo imaging strategy in human mouse and seq data, the authors show a building on adhesion molecules in vascular neutrophils leading to platelet aggregation and reduced lung infusion.
Two recently published studies have provided new insights into the long-term effects of COVID-19 on the nervous system.
Paper on hydroxychloroquine led by French researcher Didier Raoult is second-most-cited study ever to be withdrawn.
Could human–AI collaborations be the future of interdisciplinary studies?
Confidence that researchers will make decisions in the public interest will be greater between 2023 and 2024.
A hallmark of post-viral lung disease, which adds post-acute sequelae to Covid-19, is a dysplastic lung solution. CD8 + T cells give a contribution to the aberrant fixation through IFNγ and TNF induction of IL-1β in macrophages, which arrested the differentiation of alveolar type 2 cells.
Children under the age of five infected with SARS-CoV-2 produce lower levels of some immune cells than older children and adults do.